The purpose of this combo drug is to treat moderate to severe pain. Both an opioid painkiller (hydrocodone) and a non-opioid painkiller are present. The brain-based effects of hydrocodone alter how your body perceives and reacts to pain. Additionally, acetaminophen helps lower a fever.
The extended-release hydrocodone medications Zohydro ER and Hysingla ER are used to relieve severe pain round-the-clock.
Hydrocodone with extended-release should not be taken for pain on an as-needed basis.
Earlier than using this medication
If you have any of the following conditions, you shouldn't use hydrocodone:
severe respiratory difficulties or asthma; or
an obstruction in your intestines or stomach.
issues with breathing and sleep apnea;
a brain tumor, a head injury, or seizures;
addiction to drugs or alcohol, or mental disease;
kidney or liver disease
issues with your thyroid, pancreas, or gallbladder;
Breathing can be slowed or stopped by hydrocodone. Never take this medication in bigger or longer amounts than recommended. An extended-release pill shouldn't be broken, crushed, or opened. To avoid receiving a possibly lethal dose, swallow it fully.
Even at normal doses, hydrocodone has the potential to become addictive. Never give this medication to someone else, particularly if they have a history of drug abuse or addiction. The medication should be kept out of the reach of others.
OPIOID MEDICATION MISUSE CAN LEAD TO ADDICTION, OVERDOSE, OR DEATH. The drug should be kept out of the reach of others.
If you combine opioid medications with alcohol, other sedatives, or substances that slow your breathing, you run the risk of experiencing fatal adverse effects.
What's the best way to take hydrocodone?
Even at normal doses, hydrocodone has the potential to become addictive. Read all medication instructions and adhere to the guidelines on your prescription label. Never take hydrocodone for longer than recommended or in higher doses. If you experience a stronger desire to take more of this medication, let your doctor know.
Never provide an opioid medication to someone else, particularly if they have a history of drug abuse or addiction. ADDICTION, OVERDOSE, OR DEATH CAN RESULT FROM MISUSE. The drug should be kept out of the reach of others. It is illegal to sell or give away opioid medications.
An extended-release pill shouldn't be broken, crushed, or opened. To avoid receiving a possibly lethal dose, swallow it fully. Never break or crush a hydrocodone pill to inject the liquid into your vein or to ingest the powder. This may result in death.
After using this medication for a while, do not suddenly stop using it since you risk having severe withdrawal symptoms. Inquire about stopping hydrocodone safely.
Don't store unused opioid medications. Someone who unintentionally or incorrectly uses this medication could die after just one dose. Where can I find a medicine take-back disposal program? Ask your pharmacist. If there isn't a program for drug disposal, flush any unused medication down the toilet.
Zohydro(R) ER Extended-Release Capsules: Initial Dose: 10 mg Orally Every 12 Hours
Hysingla(R) ER Extended-Release Tablets: Initial dose: 20 mg orally every 24 hours
-Use of greater initial doses in non-opioid tolerant patients may result in deadly respiratory depression; patients should be continuously watched for respiratory depression, especially in the first 24 to 72 hours.
-A patient who has been receiving one of the following opioids for at least one week is considered to be opioid tolerant: oral morphine 60 mg/day, fentanyl transdermal patch 25 mcg/hour, oral oxycodone 30 mg/day, oral hydromorphone 8 mg/day, oral oxymorphone 25 mg/day, or an equivalent dose of another opioid.